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KMID : 0861420020070020148
Korean Journal of Nuclear Medicine Technology
2002 Volume.7 No. 2 p.148 ~ p.152
The effect of saliva in SCC with RIA


Kim Tae-Hoon
Kim Hyun-Joo
Seo Il-Teak
Abstract
1.Squamous Cell Carcinoma associated antigen is a subfraction of TA-4, a tumor associated antigen first described by Kato and Torigoe in 1977.
2.TA-4, obtained from squamous cell carcinoma cancer tissue of the uterine cervix, has been characterized as a glycoprotein with a molecular weight of approximately 45,000 daltons.
3.SCC antigen has been studied in other squamous cell malignancies including lung, esophagus, head and neck, anal canal and skin.
4.SCC antigen is shed naturally in sweat, saliva and other body fluids. Contamination of specimens, tray, bead dispenser or other accessories with sweat, saliva or aerosols can cause falsely elevated values.
5.To reduce the possibility of contamination, gloves should be worn in all phases of assay preparation, and when handling specimens, accessories or Reagents that will be used in SCC testing.
KEYWORD
SCC antigen, TA-4, saliva, contamination
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